Best Pharmacies in Wilkes-Barre, PA

Updated September 2026 · 7 businesses · Wilkes-Barre guide

Looking for pharmacies in Wilkes-Barre? Below you'll find 7 local options with their address, phone number, website and opening hours, plus practical advice on choosing the right one.

What they do: Retail and independent pharmacies for prescriptions, vaccines and over-the-counter medicine. Many offer drive-thru pickup, delivery and automatic refills.

This guide lists 7 pharmacies in and around Wilkes-Barre, spread across 3 ZIP codes. 1 has a phone number you can call directly from this page, 1 links to its own website, 1 is open on weekends. Listings are organized so you can compare them at a glance and contact them directly.

Top 7 Pharmacies in Wilkes-Barre

Listings are shown in no paid order: no business can pay to appear or to rank higher on this page.

1 CVS Pharmacy

Open weekendsZIP 18702
  • Address 3400 Wilkes-Barre Township Commons, Wilkes-Barre Township, PA 18702
  • Phone (570) 829-4983
  • Website cvs.com
Opening hours
Tue9 AM-7 PM
Wed9 AM-7 PM
Thu9 AM-7 PM
Fri9 AM-7 PM
Sat9 AM-5 PM
Sun11 AM-5 PM

CallDirections

2 Bedwick's Pharmacy

ZIP 18702
  • Address 452 Hazle Street, Wilkes-Barre, PA 18702

Directions

3 Harrold's

ZIP 18702
  • Address 250 Old River Road, Wilkes-Barre, PA 18702

Directions

4 Keystone Professional Pharmacy

ZIP 18702
  • Address 485 South River Street, Wilkes-Barre, PA 18702

Directions

5 The Medicine Shoppe

ZIP 18702
  • Address 100 Hazle Street, Wilkes-Barre, PA 18702

Directions

6 Nockley Family Pharmacy

ZIP 18706
  • Address 1198 South Main Street, Hanover Township, PA 18706

Directions

7 APS Pharmacy

ZIP 18705
  • Address 220 South River Street, Plains, PA 18705

Directions

How to choose pharmacies in Wilkes-Barre

  • Check that the provider is licensed. You can look up any Pennsylvania medical license on the Department of State's PALS website.
  • Confirm that they accept your insurance plan and whether you need a referral from your primary care doctor.
  • Look at hospital affiliations. Many Wilkes-Barre practices belong to a larger health system, which makes referrals and records easier.
  • Ask about wait times for new patients, telehealth visits and after-hours coverage.
  • Read recent patient reviews, but focus on patterns (communication, billing, wait times) rather than one-off complaints.

Local tips for Wilkes-Barre

Much of Wilkes-Barre sits in the Susquehanna floodplain behind the Wyoming Valley levee system, so flood insurance and basement waterproofing are common concerns for homeowners.

Scranton is about 20 minutes away, and many Wyoming Valley businesses serve Kingston, Plains, Wilkes-Barre Township and the surrounding towns.

Wilkes-Barre is in Luzerne County, and local phone numbers use the 570 and 272 area codes. Popular areas include Downtown, Parsons, Miners Mills, North End, South Wilkes-Barre, Heights, Rolling Mill Hill.

Frequently asked questions

Which pharmacies in Wilkes-Barre are open on weekends?

According to their listed hours, these are open on Saturday or Sunday: CVS Pharmacy. Hours can change on holidays, so call before you go.

Which areas of Wilkes-Barre do these pharmacies cover?

The pharmacies on this list are located in ZIP codes 18702, 18705, 18706. Many businesses also serve nearby neighborhoods and suburbs, so ask when you call.

How do I know if a doctor is board certified?

You can check board certification for free on the American Board of Medical Specialties site (CertificationMatters.org), and verify a Pennsylvania license on the state's PALS lookup.

Do I need a referral to see pharmacies in Wilkes-Barre?

It depends on your insurance. HMO plans usually require a referral from your primary care physician, while PPO plans usually don't. Call your insurer or check your plan documents before booking.

What should I bring to my first appointment?

Bring a photo ID, your insurance card, a list of current medications and doses, any recent test results and a short list of questions you want to ask.

Business data for this page comes from © OpenStreetMap contributors (ODbL), reviewed and formatted by Pennsylvania Connection.

Information is collected from public sources and may change. Please confirm hours, prices and availability directly with each business. Business owner? Ask us to update your listing.